‘Inflammation in the membrane. Inflammation in the brain!’* OCD


‘Brain Inflammation Discovered in Those With OCD.’

A study in Canada by the Centre for Addiction and Mental Health (CAMH) had demonstrated for the first time, that brain inflammation is 30 per cent higher in those of us with OCD than for those without. It is even higher if you complete an extreme number of compulsions.

The reason why this brain imaging study was significant for me was because it meant that OCD was a biological condition and not just a behavioural one; something vehemently denied by many psychologists and psychiatrists. If you have OCD this is important, because for some of us SSRIs and other treatments and medication have not worked in reducing our symptoms. Maybe this is because inflammation is partly to blame? How can symptoms be controlled if the brain is not working effectively? Treating OCD with anti-inflammatory drugs, created especially for this purpose, may hold the key to tackling OCD.

“Our research showed a strong relationship between brain inflammation and OCD, particularly in the parts of the brain known to function differently in OCD,” says Dr. Jeffrey Meyer, Head of the Neuroimaging Program in Mood & Anxiety in CAMH’s Campbell Family Mental Health Research Institute. “This finding represents one of the biggest breakthroughs in understanding the biology of OCD, and may lead to the development of new treatments.” **

Inflammation can be a positive function in the body. It tells us that our body has been damaged or is fighting off an infection; the infected areas will begin to swell as part of the natural healing process. However, surely in the brain, this is not such a good thing as it must also affect so many other cognitive functions and even cause depression, as CAMHS has proved in another imaging study. If the effects of the inflammation can be reduced, then there is hope that OCD can be minimised, because the brain will be able to concentrate on making new neural pathways rather than fighting off an infection. Thus, CBT would surely be more effective.

The study included 20 people with OCD and a comparison group of 20 people without the disorder… The researchers used a type of brain imaging called positron emission tomography (PET) that was adapted with special technology at CAMH to see inflammation in the brain. A chemical dye measured the activity of immune cells called microglia, which are active in inflammation, in six brain areas that play a role in OCD. In people with OCD, inflammation was 32 per cent higher on average in these regions. Inflammation was greater in some people with OCD as compared to others, which could reflect variability in the biology of the illness. **

The beauty of the study means that there is now a chance of simple blood-markers being made to measure the levels of inflammation, so that medication can be administered appropriately. The imaging study was also able to identify who had the highest levels of inflammation and this linked directly to those people who carried out the highest numbers of compulsions. Compulsions are what people with OCD do to relieve the anxiety that they are feeling. The PET scans showed that when people tried to stop doing their compulsions, their inflammation levels rose tangentially. Knowing this will mean that it’s possible to identify who will benefit the most from treatment with anti inflammatory medication. This inflammation may have begun after OCD started, or it may be the cause, but it’s there and must be hampering methods of treatment.

Dr Meyer concluded that:

“Medications developed to target brain inflammation in other disorders could be useful in treating OCD. Work needs to be done to uncover the specific factors that contribute to brain inflammation, but finding a way to reduce inflammation’s harmful effects and increase its helpful effects could enable us to develop a new treatment much more quickly.”

I hope that medical professionals in the U.K. take heed of this study, along that those we know and love. OCD is a complex condition that we can’t always control. However, I am now hopeful that, given the right conditions in my brain, CBT might actually work for me. I just pray the wait for targeted medication is not a long one. I can’t afford to lose any more friends.

*Title loosely based on Cypress Hill’s ‘Insane in the Brain.’

**Medical News Today, ‘OCD linked to inflammation in the brain.’ Tim Newman. 22nd June 2017.

CAMH: CAMH researchers discover brain inflammation in people with OCD http://www.camh.ca/en/hospital/about_camh/newsroom/news_releases_media_advisories_and_backgrounders/current_year/Pages/CAMH-researchers-discover-brain-inflammation-in-people-with-OCD.aspx#.WVJeEnByHc0.twitterin.

 

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A letter from my OCD brain to me.


Dear You,

I don’t want to judge you any more. I don’t want to constantly say negative things to you and make you feel worthless. To be honest, talking negatively to you all day long is exhausting and I’m beginning to believe my own rhetoric.

What I really want to do is to be able to celebrate every time you achieve something; no matter how small. I want to be able to jump up and down, squealing with excitement, because you did something that you are proud of; even if no one else notices. I would like to dwell on the serenity felt each time you see a beautiful sunset and to let you dance without disturbance, when you hear your favourite song. I must stop sabotaging all these beautiful moments for you, and learn to be silent and present instead.

Above all, what I don’t want to do anymore, is to give you a hard time. I’m not a bully, I honestly do have your best interests at heart. Always. However, when you really need me to be there for you, I often let you down.

I’m not your nemesis, even though I may come across like that most of the time. I don’t want to harm you. Conversely, I want to be able to encourage you to eat healthily, sleep deeply and love regularly. Instead, all I seem to be able to do is to make you feel sad and the sadness makes you cry. I just come across as heartless and callous and this has to stop. If I don’t stop hurting you, then you will have spent most of your life believing that you have failed. That is not how I want you to live your life anymore.

I’m telling all of this to you now, because one day soon it will be too late to tell you how much I really love you; how much I am proud of you. After all, you have survived many traumas, yet I still tell you that you are a failure and that you are unlovable. What right have I got to judge you so harshly?

What I should be saying is that I love you unconditionally. I should be telling you that your smile is enough for me. I need to explain to you that when I see you laughing, and you are always laughing, that my heart melts with pride. You are brave, loyal and kind, yet I make you doubt these truths about yourself every single day.

I need to give you a break and encourage you to love yourself. Hell, I need to love you too!

I’m gonna try to do right by you from now on beautiful.

Love from,

Your Brain xxx

OCD and Friendship.


Friendship has been so important in fighting my Mental Health condition.

Friends who have been there for me through the worst parts of my illness have been many, but those who have answered distressed calls and texts in the middle of the night are rare and epitomise a wonderful quality; that of selflessness. Those who support us often do so at great risk to their own wellbeing and that worries me. After all, who cares for the carers of OCD sufferers?

When was the last time that you sent someone who has supported you a card or letter telling them just how much they mean to you? Have you ever sent them a gift to demonstrate your gratitude, or more importantly have you tried to give them a break, some respite from your obsessions and compulsions? Our loved ones need respite from listening to us talk about OCD. When we are in the grip of our condition we talk about it a lot, did you know that? I’m not a selfish person per se, but OCD is selfish. In the grip of a severe OCD crisis, I have stolen hours from my support network and destroyed their peace of mind at the same time.

There are forums on the OCD Action and OCD UK websites for our family and friends, but have you told your loved ones that there is somewhere for them to vent their frustrations? I have told my husband, but not my friends. I’m not really sure how to tell them to be honest; maybe because I don’t want them to think that they can’t cope. Who am I to suggest to them what to do, with my background of not coping?

What could you do tonight to give a loved one some respite from your OCD?